Roads are clear after the accident on I-16 westbound mile marker 63 near the Soperton exit.
The Georgia State Patrol says that at 6:20 AM a Penske rental truck hauling a trailer with a passenger vehicle tried to enter the road from the westbound emergency lane.
The Penske truck pulled in front of a tractor trailer, which hit the rental truck. The impact caused the rental truck to separate from its trailer, run off the road into the woods, and turn over.
The driver of the rental was, 67 year old Ginette Cayard of Athens. She and her passenger were taken to Fairview Park Hospital.
The driver of the tractor trailer was 20 year old Thomas Johnson from Statesboro.
The GSP says the crash is under investigation and charges are pending.